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Saturday, April 19, 2008

Udder size independency luck

  The breast is the feminine US's symbol, the breast is only the nursing organ originally, afterward the people discovered breast after masculine hand and lip caress, the breast will inflate, the nipple slightly will also erect, then as a result of the reflex action, the womb also will contract, will be is only inferior to reproductive organ's sexy more intense spot, therefore the breast is called the second sex organs. just like the male will have the illusion, the thinking female hoped that she the companion will have the big spot penis to be the same, the female also believed that the plentiful breast will be very important to the male, longed for he will have the plentiful breast. many male and the females thought that woman's breast is bigger, is more intense to the natural stimulation's response, moreover easy to reach the high tide. Many male also have another kind of error, thought that the chest smooth female is quite slow to the stimulation response, is very low to the sexual affection interest, even simply does not have the interest. this viewpoint is in fact completely wrong, does not have the evidence to prove sufficiently absolutely breast's size concerns with the sexual affection or the natural response's degree. In fact, the woman in the breast is stroked by the human, the breast is small and the plentiful female extent of reaction does not have the difference. Thus it can be seen, the female does not need to have scruples breast's size.

Saturday, February 16, 2008

Are You a Candidate for a Cervical Cancer Vaccine?

Globally, cervical cancer is the second most common cancer in women, and in the U.S., nearly 4,000 women will die from the disease this year, according to the National Cancer Institute. Consequently, doctors and public-health experts are touting the new vaccine as a landmark drug in women’s health.
The vaccine is targeted to females 9 to 26 years old—the only age range tested in the drug’s preliminary research trials. The hitch is this: Cervical cancer typically occurs in midlife, with nearly half of the women diagnosed with the disease being between the ages of 35 and 55, according to the CDC.
The hailed advent of Gardasil, produced by pharmaceutical giant Merck, has left many women wondering whether this drug is only for the innocent young, or if it could also safeguard mature and sexually active women who are at a higher risk for cervical cancer.
Experts weigh in on who may and may not benefit from the vaccine.
Partial Immunity Better Than None
HPV is a group of viruses that includes more than 100 different strains. “You can get infected with one of these strains on your first sexual encounter, and it is not easy for your doctor to tell if you are infected,” says Dr. Harry Hull, the state epidemiologist from the Minnesota Department of Health. Dr. Hull is also one of 15 experts on the CDC’s immunization advisory committee, which will endorse federal recommendations for Gardasil later this month. These recommendations mandate how and when the vaccine should be administered, who should get it and if it is a mandatory or voluntary immunization.
If a woman is infected with an HPV strain before receiving the vaccine, future immunity against that strain is impossible. As a consequence, sexually active women and women already infected with HPV strains are not ideal candidates for the vaccine, says Dr. Hull.
But women within these categories shouldn’t discount the drug just yet. Among the many HPV strains, only four cause nearly all of the world’s cervical cancers and genital warts: Types 16 and 18, and Types 6 and 11, respectively. Gardasil is designed to target these. “So even if you've been infected with one of these strains, you are still going to benefit from vaccination against the other three strains,” says Dr. Hull.
So sexually active women may not achieve total immunity, but partial immunity is certainly better than none.
Off-Label Prescription
Gardasil is licensed only for females ages 9 to 26, and it will take years for Merck to test the vaccine’s efficacy on a broader age range. Until then, doctors may choose to prescribe Gardasil for women beyond the age of 26, but only if the conditions are right. “This means that the patient has had normal Pap smears all of her life and there is no evidence that she is infected with an HPV strain,” says Dr. Bradley Busacco, a gynecologist and obstetrician in Cincinnati, Ohio.
Not all physicians will feel comfortable prescribing the vaccine off-label. (Off-label means that the drug will be used in a way that is not specifically endorsed by its manufacturer—in this case, prescribing it for women exceeding Merck’s age recommendations.) Women beyond the age of 26 who wish to be vaccinated must discuss their medical history and the issue of off-label prescribing with their gynecologist.
Women in older age demographics may soon have another option for cervical cancer protection. By the year’s end, the FDA is expected to review and approve a second HPV vaccine, Cervarix (produced by GlaxoSmithKline). Initial studies indicate that Cervarix is safe and effective against HPV infection in women age 15 to 55 years. Unlike Gardasil, GlaxoSmithKline’s drug is not designed to immunize against genital warts, but it will protect women against the two leading cancer-causing HPV strains: Types 16 and 18. Previous infection of one of these HPV strains will compromise Cervarix’s immunity, and previous infection of both of these HPV strains will negate the vaccine’s immunity
Men: Important Members of the HPV-Infected Population
Due to a lack of research, boys and young men, even older men, are not immediate candidates for the HPV vaccines. But males are important members of the HPV-infected population, and they should not be overlooked, says one of the vaccine’s inventors, Shin-je Ghim. “Men move the virus from one woman to another. They also run the risk of contracting genital warts,” says Ghim, who is an assistant professor of immunology at the University of Louisville. “I think it would be nice if boys were immunized not only for themselves, but for their future partners, too.”
According to Merck, that day may not be far off. The company is currently testing Gardasil’s efficacy on young males, and it anticipates results within the next year or two, says Kelley Dougherty, director of public affairs for Merck vaccines.
Pregnancy
Gardasil is a pregnancy Category B drug. Studies have shown the vaccine to be safe and effective in reproduction experiments involving female rats, but Merck must conduct more human reproduction studies before recommending Gardasil during pregnancy, says Dougherty.
The vaccine is administered in a series of three injections spaced over six months, and if a woman becomes pregnant during that time frame, she should discontinue the series until her pregnancy ends. Women can then resume the vaccination where they left off. There is no need to restart the series.
In regards to Cervarix, it is too soon in the drug’s development process to make any pregnancy recommendations, according to Danielle Halstrom, director of product communications for GlaxoSmithKline.
How Early Can You Vaccinate?
Scientists have not examined Gardasil’s effectiveness on children below age 9, but there is little need to vaccinate children at birth, assures Professor Ghim. “Sexual activity—not age—is the major factor in deciding when to vaccinate someone.”
Preliminary studies indicate that Gardasil guarantees HPV immunity for at least five years and Cervarix will protect patients for at least four and a half years. Yet, researchers do not know the exact endpoints of immunity for either vaccine. Children vaccinated at birth may need a booster shot to bolster their immunity before becoming sexually active. As a result, immunization experts recommend that parents wait to vaccinate their children until they are closer to the age of sexual activity. Merck is currently conducting trials to track Gardasil’s staying power, and GlaxoSmithKline has similar longevity tests underway.
Mixing Gardasil and Cervarix
If booster shots are necessary to sustain immunity throughout a person’s lifetime, doctors will need to know if Gardasil and Cervarix are compatible vaccines. To date this issue is a matter of speculation, not hard science. “So far, nobody’s looked at mixing the two drugs,” says epidemiologist Hull. “I think that there will be some studies done on this in the future, but it probably won’t be a problem,” he says. “Gardasil and Cervarix are very closely related products.
“The bottom line is that women who may be or who already are sexually active should be encouraged to get vaccinated for HPV,” says Dr. Hull. “Immunization will save lives.”

Thursday, November 1, 2007

On call: Wife’s disinterest in sex

On call

Wife’s disinterest in sex

Q.My wife and I, who both read your column, have
always enjoyed our intimate relations. Since she went through the change last
year, however, she’s lost interest in sex. She’s only 53, and although I’m 8
years older, I’m as amorous as ever. Do you have any suggestions for us?


A.We’re glad to have you both as readers; in many
households, after all, it’s women who watch over men’s health.


Doctors have learned a lot about the male sexual response in the Viagra era,
but there is less information about female sexuality. Menopause signals an
abrupt drop in female hormones such as estrogen and progesterone, but that
shouldn’t affect the female sex drive. In fact, libido depends on
testosterone, the male hormone, in both men and women.
Testosterone levels are very much lower in women than men, but they drop even
lower as menopause approaches, then remain stable during and after menopause as
the adrenal glands continue to produce small amounts of male hormones. Still,
some women are testosterone deficient and might benefit from testosterone
therapy. Unfortunately, however, data are scant, and much more research is
needed to learn if testosterone is safe and effective — and if it is, which
women should receive it and what dose and preparations are best. At present,
those answers are a long way off; in fact, the same questions about testosterone
replacement remain to be answered for men.


Another area for research is the use of Viagra for women. An early trial
found the drug safe but not beneficial for healthy postmenopausal women. More
research is under way, and other drugs are being developed for sexual
dysfunction in both genders. The FDA has already approved a hand-held
battery-powered clitoral stimulator for women with sexual dysfunction. Your
wife’s problem, though, may be a good deal simpler. Postmenopausal women who do
not take hormone therapy (and with research showing more harm than good, most
should not) develop vaginal dryness, which can make intercourse unpleasant or
even painful. So a simple place to start would be a nonprescription vaginal
lubricant such as Replens. If that doesn’t help, your wife should ask herself if
she might be feeling subtle stress or unhappiness or if she may be reacting to
personal, marital, or family conflicts. Her doctor may be able to help her sort
out possible physiological and psychological issues.


Discuss the problem with your wife frankly, but be patient and supportive,
always looking for mutually satisfactory ways to achieve intimacy and express
love and affection.

How To Spice Up Your Sex Life

Since the dawn of time, people have looked toward elixirs and potions to
improve their sex lives. Why else, after all, would one consume ground tiger
penis, horny goat weed and Spanish Fly?


Perhaps because nearly one in five men in the U.S. suffer from erectile
dysfunction, according to a recent study in the American Journal of
Medicine
. Some researchers have estimated that as many as 40% of U.S. women
have low libido or inability to reach orgasm. Most quick fixes simply don't
work, and some, like Spanish Fly, a supposed aphrodisiac derived from beetles
that can cause kidney damage, are harmful.



In Pictures: Thirteen Steps To Better Sex


But modern medicine has found ways--both proven and experimental--to improve
your sex life. One place to start: old-fashioned remedies, which some say work
best. Regular exercise can actually improve erectile function in
most men, says Andrew McCullough, a urologist at New York University Medical
Center--and we're talking jogging, not the acrobatic feats found in the back of
a magazine. Not particularly athletic? Therapists say that paying attention to
your feelings is as important as any pill, nose spray or cream.


"Have a really wonderful role-play with your partner, have a really great
dinner out or watch a romantic movie together," says Robert Dunlap, who has
researched aphrodisiacs at the Institute for Advanced Study of Human Sexuality
in San Francisco. "The greatest aphrodisiac is your mind."


Hope In A Bottle

But that's not stopping the $600
billion global pharmaceutical industry from trying to think up new sex drugs.
Viagra, the little blue pill Pfizer launched a decade ago, brings in $1.7
billion in sales every year. Cialis, the longer-acting imitator made by Eli
Lilly, rakes in another $1 billion, with several hundred million more for
Levitra, from Bayer and Schering-Plough. Other remedies increase blood flow,
like the penis injection Caverject, and bring in $30 million more.


A product that could improve women's sexual function might bring in even more
money, if it were truly effective. So far, though, companies have been
unsuccessful. Viagra failed in tests on women. Procter & Gamble tried to
push a testosterone patch for female sexual dysfunction through the Food and
Drug Administration (FDA) but in 2004 the agency balked, citing a lack of
long-term safety data.


Now the idea of using testosterone as a sex-booster for women is being pushed
by Lincolnshire, Ill.-based BioSante Pharmaceuticals, Inc. Its LibiGel is rubbed
on the upper arm daily, delivering testosterone, which is thought to increase
libido, to the bloodstream over time. The company just began late-stage trials,
and, after discussions with the FDA, will start a big safety trial before
submitting data to regulators in 2009.


Palatin Technologies, of Cranbury, N.J., is trying to get in on the game,
developing a nose spray, called bremelanotide, to treat men and women with
sexual dysfunction. Applied 10 to 15 minutes prior to sex, it travels through
the central nervous system to increase blood flow in the penile or vaginal
tissue. The company hopes to get FDA approval for men in 2009 and women around
2011. "On the female front, we've got a chance to be first to market," says CEO
Carl Spana. "People wonder how many women will come in for treatment, but my gut
tells me they will come in."


What Really Works
Right now, the treatment available for
women with female sexual dysfunction that has been reviewed by the FDA is a
handheld vacuum that can be used with a doctor's prescription to increase blood
flow to the clitoris. Called Eros Therapy, it is made by NuGyn of Minnesota.
Devices such as this go through fewer hurdles than drugs; the Eros device has
been tested in several dozen people, compared with hundreds for a pill such as
Viagra.


Joy Davidson, a Manhattan-based certified sex therapist, worries that all
this technology may cause some people to ignore important cultural factors that
can cause sexual dysfunction. "There are agendas here that are not health-based,
they're profit-based," she says. "If you're not looking at these elements--the
emotional, psychological and cultural--then giving somebody a so-called magic
pill is not going to solve the problem."


Future Fixes
Meanwhile, drug researchers keep coming up
with even more out-there approaches. For instance, a gene therapy, which seeks
to fix erectile function by altering the DNA of cells in the penis, then
injecting them back in to the patient. It should work for six months, according
to inventor Arnold Melman, the researcher at New York's Albert Einstein College
of Medicine. He has co-founded a tiny biotech, Ion Channel Innovations, to
develop the product, which even he doesn't expect to reach the market before
2012. No gene therapy has ever been approved.


"People always say gene therapy doesn't work, but at one point it will," says
Melman. "We think this is the one."

Aphrodisiacs That Really Work

For as long as humans have been having sex, they've been trying to get in the
mood--or get their partners in the mood. And if necessity is the mother of
invention, it's no surprise that humans have developed a wide variety of creative
solutions for the old "I've-got-a-headache" problem.


The most recent solution, of course, is Viagra. But in ancient India, a young
man who proved passionless in the sack might have tried goat testicles boiled in
milk. Oysters are another common turn-on; the Roman satirist Juvenal was the
first to note their seductive qualities. In medieval times, honeyed mead was the
equivalent of Bud Lite for loosening up carousing swains.


Fresh snake blood is still revered as a stimulant in parts of Asia, as are
bat blood, reindeer penises, shark fins and ground rhino horns. And what
sad-sack hasn't at least contemplated Spanish Fly? It's not a fly at all,
actually, but the dried remains of beetles, which irritate the male urogenital
tract, causing a prolonged erection--and potentially causing serious discomfort
and even death, according to the Food and Drug Administration.


In
Pictures: Ten Aphrodisiacs That Work


Beyond their collective exoticism, the only thing the above have in common is
that they don't work. Named for Aphrodite, the Greek goddess of sex and beauty,
an aphrodisiac is just about anything that awakens or increases sexual
desire--be it your own, or the object of your desire's. In reality, however,
most aphrodisiacs are folklore at best and hazardous to your health at worst. As
the Food and Drug Administration has declared: "There is no scientific proof
that any over-the-counter aphrodisiacs work to treat sexual dysfunction."


But there is still some hope for those seeking a libido boost. The herbal
supplement Ginkgo
Biloba is being studied by the Office of Dietary Supplements, a subsidiary
of the National Institute of Health, as a treatment for erectile dysfunction.
The FDA has called animal studies of yohimbine "encouraging." Derived from the
bark of an African tree, yohimbe has been used as a sexual stimulant for
centuries. But the FDA notes that animal studies can't be used to prove
effectiveness in humans.


Even when aphrodisiacs do show promise, they don't always work for everybody.
Sexual desire is rooted in the mind more than the genitals. One person's fantasy
could be another's turn-off. "We're all unique individuals, and we all respond
differently to different things," says Dr. Beverly Whipple, a professor emerita
at Rutgers University and author of, most recently, The Science of Orgasm.


At the root of human sexual desire is the "core erotic personality"--a.k.a.
"sexual template"--which, in a nutshell, is whatever gets you off. "Everyone has
in their mind an image of someone or thing they find sexually desirous,"
explains Dr. William Granzig, dean of clinical sexology at Maimonides University
in North Miami Beach and president of the American Board of Sexology.


That image might be a person of specific age, race or hair color, or it might
be every person. It could be a fondness for a particular style of dress, objects
such as women's shoes or fur-lined handcuffs, or behavior such as cross-dressing
or exhibitionism. Whatever it is in particular, the sexual template is believed
to develop early on during a childhood erotic experience--perhaps as early as
age three or four--and it sticks with you for life.


The difficulty of maintaining sexual desire over the long term, of course, is
that if your partner falls outside of your sexual template--or you fall outside
theirs--sooner or later one of you could lose interest. "Many people whose
template is not, say, age-specific, can have great sex throughout their lives,"
notes Granzig. "But if you're only attracted to 20-year-olds, once your partner
hits 30, your desire will decrease. Unless, of course, you can figure out some
ways to spice things up."


Spicing things up is where sex gets complicated, because men and women
sometimes have wildly divergent desires. For men, a sexy photo is often enough to get blood flowing in the right direction. For
women, pornography can be a major turn-off. Orgasms are also less central to
women, who sometimes need full body stimulation, not to mention mental
seduction, in order to achieve climax. "There are just so many variables that go
beyond the physical in sex for women," says Dr. Janice Epp, a clinical
sexologist at the Institute for Advanced Study of Human Sexuality in San
Francisco.


There are also a host of external nuisances that weigh heavily upon sexual
desire--and that may dampen the mood. Studies routinely rank American culture as
one of the most sexually repressed in the world thanks to its forbidding
Judeo-Christian origins, high incidence of sexual problems and dysfunction, and
a lingering Puritan discomfort with the very topic of sex.


And while Europeans take mandatory month-long vacations, Americans routinely
work 60-hour weeks, and stretch their ten vacation days over the entire year.
With the demands of our modern day technological society, it's little wonder the
search for aphrodisiacs continues. "I see a lot of highly evolved, highly
skilled people who are losing desire because they have such an overriding focus
on their profession," says Epp, who works in Silicon Valley. "For them, the
temptation to believe that there's a magic pill that will make them desirous of
sex again is very strong."


Inspired by the phenomenal success of Viagra, which rang up over $1.6 billion
in sales for Pfizer in 2005, it's perhaps not surprising that there has been a
recent push to find more pharmaceutical remedies for flagging sexual desire.
It's a focus that throws many in the sex field into apoplexy. "The idea that you
can just give someone a pill, and they'll be interested in sex is like putting a
band-aid on a tumor," says Epp.


In the end, the only truly effective aphrodisiac seems to be that's been
working for humans all along. "Your biggest sex organ is the one between your
ears," says Dr. Granzig. "What is desire, after all, other than the hope that
you can fulfill your sexual fantasies? And that's all in your mind."

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